169340-04-9
169340-04-9
Chemical Structure
ZM 253270
- CAS. Nr.: 169340-04-9
- Formula:C22H26ClN7O3
- Molecular Weight:471.94
IUPAC Name: (E)-4-((4-chlorophenyl)amino)-2-(4-(2-(hydroxyimino)propanoyl)piperazin-1-yl)-6-isopropyl-5,6-dihydro-7H-pyrrolo[3,4-d]pyrimidin-7-one
InChIKey: OYOSXTKSOATNNB-MZJWZYIUSA-N
SMILES: O=C(N1CCN(CC1)C2=NC(C(N(C(C)C)C3)=O)=C3C(NC4=CC=C(C=C4)Cl)=N2)/C(C)=N/O
Biological Activity: ZM 253270 is a species-selective non-peptide NK-2 receptor (NK-2R) antagonist. ZM 253270 competitively inhibits the binding of [3H]NKA to native or cloned NK-2R from hamster bladder (Ki=2 nM), but has a weaker inhibitory effect (48-fold) on the binding of [3H]NKA to cloned human NK-2R[1].
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ZM 253270 | ZM 253270 is a species-selective non-peptide NK-2 receptor (NK-2R) antagonist. ZM 253270 competitively inhibits the binding of [3H]NKA to native or cloned NK-2R from hamster bladder (Ki=2 nM), but has a weaker inhibitory effect (48-fold) on the binding of [3H]NKA to cloned human NK-2R. | |||||||||||||||||||||
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