1695533-44-8
1695533-44-8
Chemical Structure
Erastin2
- CAS No.: 1695533-44-8
- Formula:C36H35ClN4O4
- Molecular Weight:623.14
IUPAC Name: 2-((4-(2-(4-chlorophenoxy)acetyl)piperazin-1-yl)methyl)-3-(4-isopropoxy-[1,1'-biphenyl]-3-yl)quinazolin-4(3H)-one
InChIKey: WLPHOTYCGOGILE-UHFFFAOYSA-N
SMILES: O=C1C2=C(N=C(CN3CCN(CC3)C(COC4=CC=C(C=C4)Cl)=O)N1C5=C(OC(C)C)C=CC(C6=CC=CC=C6)=C5)C=CC=C2
Biological Activity: Erastin2, an Erastin (HY-15763) analog, is a ferroptosis inducer and a potent, selective inhibitor of the system xc(-) cystine/glutamate transporter[1][2][3][4]
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Erastin2 | 98.76% | Erastin2, an Erastin (HY-15763) analog, is a ferroptosis inducer and a potent, selective inhibitor of the system xc(-) cystine/glutamate transporter | ||||||||||||||||||||
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References
- [1]. Conlon M, et al. A compendium of kinetic modulatory profiles identifies ferroptosis regulators[J]. Nat Chem Biol. 2021 Jun;17(6):665-674. [Content Brief]
- [2]. Cao JY, et al. A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity. Cell Rep. 2019 Feb 5;26(6):1544-1556.e8. [Content Brief]
- [3]. Dixon SJ, et al. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. Elife. 2014 May 20;3:e02523. [Content Brief]
- [4]. Tarangelo A, et al. p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells. Cell Rep. 2018 Jan 16;22(3):569-575. [Content Brief]
Keywords
