17105-15-6
Chemical Structure
Epsilon-(gamma-glutamyl)-lysine
Synonym(s): H-Glu(H-Lys-OH)-OH; γ-Glu-ε-Lys
- CAS 番号: 17105-15-6
- Formula:C11H21N3O5
- Molecular Weight:275.30
IUPAC Name: N6-((S)-4-amino-4-carboxybutanoyl)-L-lysine
InChIKey: JPKNLFVGUZRHOB-YUMQZZPRSA-N
SMILES: OC([C@@H](N)CCC(NCCCC[C@H](N)C(O)=O)=O)=O
Biological Activity: Epsilon-(gamma-glutamyl)-lysine (H-Glu (H-Lys-OH)-OH) is an isodipeptide formed during the proteolytic degradation of proteins containing Nε-(γ-glutamyl)-lysine cross-links. Epsilon-(gamma-glutamyl)-lysine serves as a substrate for γ-glutamylamine cyclotransferase, which specifically cleaves it. Epsilon-(gamma-glutamyl)-lysine is applicable to studies related to transglutaminase-mediated protein cross-linking and turnover, γ-glutamylamine cyclotransferase activity, glaucoma, and tissue scar formation[1][2][3].
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Epsilon-(gamma-glutamyl)-lysine | 99.90% | Epsilon-(gamma-glutamyl)-lysine (H-Glu (H-Lys-OH)-OH) is an isodipeptide formed during the proteolytic degradation of proteins containing Nε-(γ-glutamyl)-lysine cross-links. Epsilon-(gamma-glutamyl)-lysine serves as a substrate for γ-glutamylamine cyclotransferase, which specifically cleaves it. Epsilon-(gamma-glutamyl)-lysine is applicable to studies related to transglutaminase-mediated protein cross-linking and turnover, γ-glutamylamine cyclotransferase activity, glaucoma, and tissue scar formation. | ||||||||||||||||||||
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- [1]. Fesus L, et al. Formation of Nε-(γ-glutamyl)-lysine isodipeptide in Chinese-hamster ovary cells. Biochem J. 1989;263:843-848.
- [2]. El Nahas AM, et al. Elevated ε-(γ-Glutamyl)lysine in Human Diabetic Nephropathy Results from Increased Expression and Cellular Release of Tissue Transglutaminase. Nephron Clin Pract. 2004;97:c108-c117. [Content Brief]
- [3]. Priglinger SG, et al. Potential role of tissue transglutaminase in glaucoma filtering surgery. Investigative ophthalmology & visual science. 2006 Sep;47(9):3835-45. [Content Brief]
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