171179-37-6
Chemical Structure
BPIQ-II hydrochloride
Synonym(s): PD 158294
- CAS No.: 171179-37-6
- Formula:C15H11BrClN5
- Molecular Weight:376.64
IUPAC Name: N-(3-bromophenyl)-1H-imidazo[4,5-g]quinazolin-8-amine hydrochloride
InChIKey: FENLVGDZGJBHPT-UHFFFAOYSA-N
SMILES: BrC1=CC(NC2=NC=NC3=C2C=C4NC=NC4=C3)=CC=C1.Cl
Biological Activity: BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50=8 pM). It is selective for EGFR over an assortment of other tyrosine and serine/threonine kinases. Cellular studies indicate that BPIQ-II can enter cells and very selectively shut down EGF-stimulated signal transmission by binding competitively at the ATP site of EGFR.
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BPIQ-II hydrochloride | BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50=8 pM). It is selective for EGFR over an assortment of other tyrosine and serine/threonine kinases. Cellular studies indicate that BPIQ-II can enter cells and very selectively shut down EGF-stimulated signal transmission by binding competitively at the ATP site of EGFR. | |||||||||||||||||||||
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Keywords
