177785-47-6
Chemical Structure
PD 161374
- CAS No.: 177785-47-6
- Formula:C13H15NO3S
- Molecular Weight:265.33
IUPAC Name: (2S,3S)-3-methyl-2-(3-oxobenzo[d]isothiazol-2(3H)-yl)pentanoic acid
InChIKey: FUSYFEXGXRDJNB-KWQFWETISA-N
SMILES: CC[C@H](C)[C@H](N1SC2=CC=CC=C2C1=O)C(O)=O
Biological Activity: PD 161374 is an inhibitor targeting the HIV-1 nucleocapsid protein NCp7. PD 161374 primarily acts on the early stages of viral replication, inhibiting the completion of reverse transcription without affecting viral entry or later assembly. PD 161374 remains active against HIV-1, HIV-2, SIV, and drug-resistant strains. PD 161374 can be used to study antiretroviral agents[1][2].
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PD 161374 | PD 161374 is an inhibitor targeting the HIV-1 nucleocapsid protein NCp7. PD 161374 primarily acts on the early stages of viral replication, inhibiting the completion of reverse transcription without affecting viral entry or later assembly. PD 161374 remains active against HIV-1, HIV-2, SIV, and drug-resistant strains. PD 161374 can be used to study antiretroviral agents. | |||||||||||||||||||||
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- [1]. Sharmeen L, et al. Inhibition of the early phase of HIV replication by an isothiazolone, PD 161374. Antiviral Res. 2001 Feb;49(2):101-14. [Content Brief]
- [2]. Ouhtit A. Synthesis and anti-retroviral activity of novel 1, 2-benzisothiazol-3 (2H)-one benzenesulfonamides targeting the HIV nucleocapsid protein 7.
Keywords
