1778671-05-8
Chemical Structure
GDC-0425 hydrochloride
Synonym(s): RG-7602 hydrochloride
- CAS No.: 1778671-05-8
- Formula:C18H21Cl2N5O
- Molecular Weight:394.30
InChIKey: XAQHOBZBBAFJDT-UHFFFAOYSA-N
SMILES: N#CC1=NC=C2NC3=C(C2=C1OC4CCN(CC4)CC)C=CC=N3.Cl.Cl
Biological Activity: GDC-0425 hydrochloride (RG-7602 hydrochloride) is an orally active, highly selective ChK1 inhibitor. GDC-0425 hydrochloride abrogates cell cycle arrest and inhibits genomic repair. GDC-0425 hydrochloride potently suppresses Gemcitabine (HY-17026)-induced pCDK1/2 expression. GDC-0425 hydrochloride can be used in research related to osteosarcoma, ovarian cancer, basal (triple-negative) breast cancer, and colorectal cancer[1][2][3].
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GDC-0425 hydrochloride | GDC-0425 hydrochloride (RG-7602 hydrochloride) is an orally active, highly selective ChK1 inhibitor. GDC-0425 hydrochloride abrogates cell cycle arrest and inhibits genomic repair. GDC-0425 hydrochloride potently suppresses Gemcitabine (HY-17026)-induced pCDK1/2 expression. GDC-0425 hydrochloride can be used in research related to osteosarcoma, ovarian cancer, basal (triple-negative) breast cancer, and colorectal cancer. | |||||||||||||||||||||
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- [1]. Xiao Ding, et al. A supported liquid extraction LC-MS/MS method for determination of concentrations of GDC-0425, a small molecule Checkpoint kinase 1 inhibitor, in human plasma. Biomed Chromatogr. 2016 Dec;30(12):1984-1991. [Content Brief]
- [2]. Jeffrey R Infante, et al. Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors. Clin Cancer Res. 2017 May 15;23(10):2423-2432. [Content Brief]
- [3]. Lee HJ, Cao Y, Pham V, et al.. Ras-MEK Signaling Mediates a Critical Chk1-Dependent DNA Damage Response in Cancer Cells. Molecular cancer therapeutics. 2017 Apr;16(4):694-704. [Content Brief]
Keywords
