1802395-34-1
Chemical Structure
ADAM17-IN-1
- CAS No.: 1802395-34-1
- Formula:C40H55N5O4
- Molecular Weight:669.90
SMILES: CCC[C@@H](CNC(C1=O)=O)N1C[C@H](CCC2)N2C[C@H](N3C[C@@H](N(C(C3=O)=O)CCC4=CC=CC=C4)CC5=CC=CC=C5)CC6CCCCC6
Biological Activity: ADAM17-IN-1 is a selective inhibitor of ADAM17. ADAM17-IN-1 inhibits ADAM17 activity to reduce metabolic activity of dendritic cells (DCs), impair DC antigen-presenting function, suppress allergen-specific Th2 cell polarization, and reduce Th2 cytokine (IL-4, IL-5, IL-13) secretion. ADAM17-IN-1 demonstrates protective efficacy against house dust mite (HDM)-induced type 2/eosinophilic airway inflammation in mice. ADAM17-IN-1 can be used for the study of type 2-high allergic asthma[1].
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ADAM17-IN-1 | ADAM17-IN-1 is a selective inhibitor of ADAM17. ADAM17-IN-1 inhibits ADAM17 activity to reduce metabolic activity of dendritic cells (DCs), impair DC antigen-presenting function, suppress allergen-specific Th2 cell polarization, and reduce Th2 cytokine (IL-4, IL-5, IL-13) secretion. ADAM17-IN-1 demonstrates protective efficacy against house dust mite (HDM)-induced type 2/eosinophilic airway inflammation in mice. ADAM17-IN-1 can be used for the study of type 2-high allergic asthma. | |||||||||||||||||||||
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