181477-43-0
Chemical Structure
Disomotide
Synonym(s): G209-2M; GP100:209-217(210M); MPS-22
- CAS No.: 181477-43-0
- Formula:C47H74N10O14S
- Molecular Weight:1035.21
IUPAC Name: (S)-4-(((S)-5-amino-1-(((S)-1-((S)-2-(((S)-1-(((S)-1-(((S)-1-carboxy-2-methylpropyl)amino)-3-hydroxy-1-oxopropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)amino)-1,5-dioxopentan-2-yl)amino)-3-((S)-2-((2S,3S)-2-amino-3-methylpentanamido)-4-(methylthio)butanamido)-4-oxobutanoic acid
InChIKey: BDQMCYCLZBSYJZ-BBXCZNCNSA-N
SMILES: O=C(N(CCC1)[C@@H]1C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(O)=O)C(C)C)=O)=O)CC2=CC=CC=C2)=O)[C@H](C(C)C)NC([C@H](CCC(N)=O)NC([C@H](CC(O)=O)NC([C@H](CCSC)NC([C@@H](N)[C@@H](C)CC)=O)=O)=O)=O
Biological Activity: Disomotide (G209-2M) is a melanoma antigen that enhances the generation of cytotoxic T lymphocytes (CTL) recognizing native G209 as well as melanoma[1][2].
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Disomotide | Disomotide (G209-2M) is a melanoma antigen that enhances the generation of cytotoxic T lymphocytes (CTL) recognizing native G209 as well as melanoma. | |||||||||||||||||||||
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References
- [1]. Yang S, et al. Antimelanoma activity of CTL generated from peripheral blood mononuclear cells after stimulation with autologous dendritic cells pulsed with melanoma gp100 peptide G209-2M is correlated to TCR avidity. J Immunol. 2002 Jul 1;169(1):531-9. [Content Brief]
- [2]. Ahmadzadeh M, et al. IL-2 and IL-15 each mediate de novo induction of FOXP3 expression in human tumor antigen-specific CD8 T cells. J Immunother. 2007 Apr;30(3):294-302. [Content Brief]
