181490-18-6
Chemical Structure
A 131701
- CAS No.: 181490-18-6
- Formula:C24H24N4O3S
- Molecular Weight:448.54
IUPAC Name: 3-(2-((3aR,9bR)-6-methoxy-1,3,3a,4,5,9b-hexahydro-2H-benzo[e]isoindol-2-yl)ethyl)pyrido[2',3':4,5]thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
InChIKey: OLPQNRLJYOGSGV-WMLDXEAASA-N
SMILES: O=C1NC(C2=NC=CC=C2S3)=C3C(N1CCN4C[C@]5([H])CCC6=C(OC)C=CC=C6[C@]5([H])C4)=O
Biological Activity: A 131701 is a selective α1a- (Ki: 0.22 nM for human α1a) and α1d-adrenoceptor antagonist. A 131701 antagonizes epinephrine-induced increases in intraurethral pressure (IUP). A 131701 causes transient decreases in mean arterial blood pressure (MABP) and transient tachycardia. A 131701 can be used in the research of spontaneous hypertension[1].
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A 131701 | A 131701 is a selective α1a- (Ki: 0.22 nM for human α1a) and α1d-adrenoceptor antagonist. A 131701 antagonizes epinephrine-induced increases in intraurethral pressure (IUP). A 131701 causes transient decreases in mean arterial blood pressure (MABP) and transient tachycardia. A 131701 can be used in the research of spontaneous hypertension. | |||||||||||||||||||||
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Keywords
