1832577-07-7
Chemical Structure
(R)-MLT-985
- CAS No.: 1832577-07-7
- Formula:C17H15Cl2N9O2
- Molecular Weight:448.27
IUPAC Name: (R)-1-(5-chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)-3-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]pyrimidin-6-yl)urea
InChIKey: GBIASRXDYFFUED-SECBINFHSA-N
SMILES: O=C(NC1=CC(Cl)=C(N2N=CC=N2)N=C1)NC3=C([C@H](OC)C)N4C(N=C3)=CC(Cl)=N4
Biological Activity: (R)-MLT-985 is the R configuration of MLT-985 (HY-142648). MLT-985 is a selective allosteric and orally active MALT1 inhibitor with an IC50 value of 3 nM. MLT-985 can suppress cell growth and aberrant CARD11/BCL10/MALT1 complex signaling. MLT-985 can be used for the research of cancer, such as B cell malignancies[1][2].
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(R)-MLT-985 | (R)-MLT-985 is the R configuration of MLT-985 (HY-142648). MLT-985 is a selective allosteric and orally active MALT1 inhibitor with an IC50 value of 3 nM. MLT-985 can suppress cell growth and aberrant CARD11/BCL10/MALT1 complex signaling. MLT-985 can be used for the research of cancer, such as B cell malignancies. | |||||||||||||||||||||
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- [1]. Quancard J, et al. Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood. J Med Chem. 2020 Dec 10;63(23):14594-14608. [Content Brief]
- [2]. Sara Elgamal, et al. Development of ZE66-0205, a Novel MALT1 Degrader for Treatment of B-Cell Malignancies, Blood, Volume 144, Supplement 1, 2024, Page 2783, ISSN 0006-4971.
Keywords
