1847-63-8
1847-63-8
Chemical Structure
Nafoxidine hydrochloride
Synonym(s): Nafoxidene hydrochloride
- CAS No.: 1847-63-8
- Formula:C29H32ClNO2
- Molecular Weight:462.02
IUPAC Name: 1-(2-(4-(6-methoxy-2-phenyl-3,4-dihydronaphthalen-1-yl)phenoxy)ethyl)pyrrolidine hydrochloride
InChIKey: HJOOGTROABIIIU-UHFFFAOYSA-N
SMILES: [H]Cl.COC1=CC2=C(C=C1)C(C3=CC=C(C=C3)OCCN4CCCC4)=C(C5=CC=CC=C5)CC2
Biological Activity: Nafoxidine hydrochloride is a non-steroidal estrogen receptor antagonist with antitumor activity for breast cancer[1][2][3].
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Nafoxidine hydrochloride | Nafoxidine hydrochloride is a non-steroidal estrogen receptor antagonist with antitumor activity for breast cancer. | |||||||||||||||||||||
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References
- [1]. Sato M, Rippy MK, Bryant HU. Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats. FASEB J. 1996;10(8):905-912. [Content Brief]
- [2]. De Lorenzo MS, Farina HG, Alonso DF, Gomez DE. Role of protein kinase C-dependent signaling pathways in the antiangiogenic properties of nafoxidine. Anticancer Res. 2004;24(3a):1737-1743. [Content Brief]
- [3]. Yaz G, Kabadere S, Oztopçu P, Durmaz R, Uyar R. Comparison of the antiproliferative properties of antiestrogenic drugs (nafoxidine and clomiphene) on glioma cells in vitro. Am J Clin Oncol. 2004;27(4):384-388. [Content Brief]
