18903-23-6
18903-23-6
Chemical Structure
NSC116565
- CAS. Nr.: 18903-23-6
- Formula:C6H5N3O3S
- Molecular Weight:199.19
InChIKey: MYPICMPDMGFOBX-UHFFFAOYSA-N
SMILES: O=C1NC2=C(C(N1O)=O)SC(C)=N2
Biological Activity: NSC116565 is an Antibacterial agent, Herbicide, and competitive Ketol-acid reductoisomerase inhibitor, with a Ki of 95.4 nM against Mycobacterium tuberculosis MtKARI. NSC116565 inhibits the growth of mycobacteria by disrupting the branched-chain amino acid biosynthesis pathway, and also inhibits the growth of weeds and brassicas. NSC116565 can be used in tuberculosis-related research[1][2][3].
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NSC116565 | NSC116565 is an Antibacterial agent, Herbicide, and competitive Ketol-acid reductoisomerase inhibitor, with a Ki of 95.4 nM against Mycobacterium tuberculosis MtKARI. NSC116565 inhibits the growth of mycobacteria by disrupting the branched-chain amino acid biosynthesis pathway, and also inhibits the growth of weeds and brassicas. NSC116565 can be used in tuberculosis-related research. | |||||||||||||||||||||
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References
- [1]. Lin X, et al. A Ketol-Acid Reductoisomerase Inhibitor That Has Antituberculosis and Herbicidal Activity. Chemistry (Weinheim an der Bergstrasse, Germany). 2025 Jun 26;31(36):e202501158. [Content Brief]
- [2]. Lin X, et al. Discovery of a Pyrimidinedione Derivative with Potent Inhibitory Activity against Mycobacterium tuberculosis Ketol-Acid Reductoisomerase. Chemistry (Weinheim an der Bergstrasse, Germany). 2021 Feb 10;27(9):3130-3141. [Content Brief]
- [3]. Guida M, et al. Amino Acid Biosynthesis Inhibitors in Tuberculosis Drug Discovery. Pharmaceutics. 2024 May 28;16(6):725. [Content Brief]
