19160-62-4
Chemical Structure
WR 30090
- CAS No.: 19160-62-4
- Formula:C25H28Cl4N2O
- Molecular Weight:514.31
IUPAC Name: 2-(dibutylamino)-1-(6,8-dichloro-2-(3,4-dichlorophenyl)quinolin-4-yl)ethan-1-ol
InChIKey: PGLJCSZNFGDTFZ-UHFFFAOYSA-N
SMILES: ClC=1C=C(Cl)C2=NC(=CC(=C2C1)C(O)CN(CCCC)CCCC)C=3C=CC(Cl)=C(Cl)C3
Biological Activity: WR 30090 (Compound 37) is a broad-spectrum antimalarial agent that does not rely on the classical antifolate pathway. WR 30090 exhibits strong activity against a variety of chloroquine-sensitive and resistant Plasmodium falciparum strains, especially the highly resistant Vietnamese strain. WR 30090 shows high activity in mouse malaria tests, with a minimum effective dose of 5 mg/kg and a minimum cure dose of 20 mg/kg. WR 30090 can be used for research on acute malaria[3][4][5].
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WR 30090 | WR 30090 (Compound 37) is a broad-spectrum antimalarial agent that does not rely on the classical antifolate pathway. WR 30090 exhibits strong activity against a variety of chloroquine-sensitive and resistant Plasmodium falciparum strains, especially the highly resistant Vietnamese strain. WR 30090 shows high activity in mouse malaria tests, with a minimum effective dose of 5 mg/kg and a minimum cure dose of 20 mg/kg. WR 30090 can be used for research on acute malaria. | |||||||||||||||||||||
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Keywords
