1948229-21-7
1948229-21-7
Chemical Structure
Eliapixant
Synonym(s): BAY 1817080
- CAS No.: 1948229-21-7
- Formula:C22H21F3N4O3S
- Molecular Weight:478.49
IUPAC Name: 3-(5-methylthiazol-2-yl)-5-(((R)-tetrahydrofuran-3-yl)oxy)-N-((R)-1-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)benzamide
InChIKey: GTQPEQGDLVSFJO-CXAGYDPISA-N
SMILES: C[C@H](C1=CN=C(C(F)(F)F)N=C1)NC(C2=CC(O[C@@H]3CCOC3)=CC(C4=NC=C(S4)C)=C2)=O
Biological Activity: Eliapixant (BAY 1817080) is a potent and selective antagonist of P2X3 receptor, with an IC50 of 8 nM. Eliapixant can be used for the research of refractory chronic cough[1][2].
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Eliapixant | 99.70% | Eliapixant (BAY 1817080) is a potent and selective antagonist of P2X3 receptor, with an IC50 of 8 nM. Eliapixant can be used for the research of refractory chronic cough. | ||||||||||||||||||||
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Eliapixant (Standard) | ≥98% | Eliapixant (Standard) is the analytical standard of Eliapixant (HY-109170). This product is intended for research and analytical applications. Eliapixant (BAY 1817080) is a potent and selective antagonist of P2X3 receptor, with an IC50 of 8 nM. Eliapixant can be used for the research of refractory chronic cough. | ||||||||||||||||||||
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References
- [1]. Spinaci A, et, al. P2X3 Receptor Ligands: Structural Features and Potential Therapeutic Applications. Front Pharmacol. 2021 Apr 13;12:653561. [Content Brief]
- [2]. Morice A, et, al. Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study. Eur Respir J. 2021 May 13;2004240. [Content Brief]
