194874-06-1
Chemical Structure
Apoptolidin
- CAS. Nr.: 194874-06-1
- Formula:C58H96O21
- Molecular Weight:1129.37
IUPAC Name: (3E,5E,7E,9R,10R,11E,13E,17S,18S,20S)-10-(((2R,3S,4S,5R,6S)-3,4-dihydroxy-5-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-20-((R)-((2R,3R,4S,5R,6R)-2,4-dihydroxy-6-((R)-2-(((2R,4S,5S,6S)-4-hydroxy-5-(((2S,4R,5R,6R)-5-hydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3-methoxypropyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)(hydroxy)methyl)-17-hydroxy-18-methoxy-3,5,7,9,13-pentamethyloxacycloicosa-3,5,7,11,13-pentaen-2-one
InChIKey: WILMROCKORZEMQ-AIUMZUNXSA-N
SMILES: O[C@H]([C@](OC(/C(C)=C/C(C)=C/C(C)=C/[C@H]1C)=O)([H])C[C@@H]([C@H](CC/C=C(/C=C/[C@H]1O[C@H](O[C@H]2C)[C@H]([C@@H]([C@H]2OC)O)O)C)O)OC)[C@](O[C@@H]([C@@H]3C)C[C@H](COC)O[C@H](O[C@H]4C)C[C@](O)([C@H]4O[C@H](O[C@@H]5C)C[C@H]([C@@H]5O)OC)C)([C@@H]([C@H]3O)C)O
Biological Activity: Apoptolidin is a polyketide isolated from Nocardiopsis bacteria[1]. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Apoptolidin | 95.60% | Apoptolidin is a polyketide isolated from Nocardiopsis bacteria. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells. | ||||||||||||||||||||
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References
- [1]. J W Kim, et al. Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp. J Antibiot (Tokyo). 1997 Jul;50(7):628-30. [Content Brief]
- [2]. A R Salomon, et al. Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14766-71. [Content Brief]
