1. Membrane Transporter/Ion Channel
    Apoptosis
  2. ATP Synthase
    Apoptosis
  3. Apoptolidin

Apoptolidin 

Cat. No.: HY-126679
Handling Instructions

Apoptolidin is a polyketide isolated from Nocardiopsis bacteria. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells.

For research use only. We do not sell to patients.

Apoptolidin Chemical Structure

Apoptolidin Chemical Structure

CAS No. : 194874-06-1

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Description

Apoptolidin is a polyketide isolated from Nocardiopsis bacteria[1]. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells[1][2].

In Vitro

Apoptolidin has cytotoxicity against normal and transformed cells, it against RG-E1A-7,RG-E1A19K-2, RG-E1A54K-9, RG-E1-4 and Adl2-3Y1 with IC50 values of 11 ng/ml,10 ng/ml,13 ng/ml, 10 ng/ml and 17 ng/ml, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1129.37

Formula

C58H96O21

CAS No.
SMILES
Structure Classification
Source

Nocardiopsis

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥95.0%

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Apoptolidin
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