1. Membrane Transporter/Ion Channel
    Apoptosis
  2. ATP Synthase
    Apoptosis
  3. Apoptolidin

Apoptolidin 

Cat. No.: HY-126679
Handling Instructions

Apoptolidin is a polyketide isolated from Nocardiopsis bacteria. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells.

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Apoptolidin Chemical Structure

Apoptolidin Chemical Structure

CAS No. : 194874-06-1

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Description

Apoptolidin is a polyketide isolated from Nocardiopsis bacteria[1]. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells[1][2].

In Vitro

Apoptolidin has cytotoxicity against normal and transformed cells, it against RG-E1A-7,RG-E1A19K-2, RG-E1A54K-9, RG-E1-4 and Adl2-3Y1 with IC50 values of 11 ng/ml,10 ng/ml,13 ng/ml, 10 ng/ml and 17 ng/ml, respectively[1].

Molecular Weight

1129.37

Formula

C₅₈H₉₆O₂₁

CAS No.

194874-06-1

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Keywords:

ApoptolidinATP SynthaseApoptosispolyketideF0F1-ATPasecancerapoptoticRG-E1A-7RG-E1A19K-2RG-E1A54K-9RG-E1-4Inhibitorinhibitorinhibit

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Apoptolidin
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