19889-23-7
Chemical Structure
Continentalic acid
- CAS No.: 19889-23-7
- Formula:C20H30O2
- Molecular Weight:302.45
IUPAC Name: (1R,4aS,4bR,7R,10aS)-1,4a,7-trimethyl-7-vinyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene-1-carboxylic acid
InChIKey: MHVJRKBZMUDEEV-XIHRTOKZSA-N
SMILES: C[C@]12[C@@](CCC3=C[C@](C=C)(C)CC[C@@]23[H])([H])[C@@](C)(CCC1)C(O)=O
Biological Activity: Continentalic acid is a diterpenoid organic acid. Continentalic acid exhibits multiple activities including anti-inflammatory, antioxidant, neuroprotective, antibacterial and antitumor effects. Continentalic acid alleviates oxidative stress, reduces pro-inflammatory cytokine production, inhibits MAPK phosphorylation and neutrophil infiltration, and induces growth inhibition and apoptosis of cancer cells. Continentalic acid can be used in research related to traumatic brain injury, cancer, inflammation and infections[1][2][3][4][5].
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Continentalic acid | 99.72% | Continentalic acid is a diterpenoid organic acid. Continentalic acid exhibits multiple activities including anti-inflammatory, antioxidant, neuroprotective, antibacterial and antitumor effects. Continentalic acid alleviates oxidative stress, reduces pro-inflammatory cytokine production, inhibits MAPK phosphorylation and neutrophil infiltration, and induces growth inhibition and apoptosis of cancer cells. Continentalic acid can be used in research related to traumatic brain injury, cancer, inflammation and infections. | ||||||||||||||||||||
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Continentalic acid (Standard) | ≥98% | Continentalic acid (Standard) is the analytical standard of Continentalic acid (HY-N6908). This product is intended for research and analytical applications. Continentalic acid is a diterpenoid organic acid. Continentalic acid exhibits multiple activities including anti-inflammatory, antioxidant, neuroprotective, antibacterial and antitumor effects. Continentalic acid alleviates oxidative stress, reduces pro-inflammatory cytokine production, inhibits MAPK phosphorylation and neutrophil infiltration, and induces growth inhibition and apoptosis of cancer cells. Continentalic acid can be used in research related to traumatic brain injury, cancer, inflammation and infections. | ||||||||||||||||||||
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- [1]. Kwon TO, et al. Continentalic acid from Aralia continentalis induces growth inhibition and apoptosis in HepG2 cells. Arch Pharm Res. 2008;31(9):1172-1178. [Content Brief]
- [2]. Ali H, et al. Attenuation of LPS-induced acute lung injury by continentalic acid in rodents through inhibition of inflammatory mediators correlates with increased Nrf2 protein expression. BMC Pharmacol Toxicol. 2020;21(1):81. Published 2020 Nov 25. [Content Brief]
- [3]. Hong R, et al. Continentalic Acid Rather Than Kaurenoic Acid Is Responsible for the Anti-Arthritic Activity of Manchurian Spikenard In Vitro and In Vivo. Int J Mol Sci. 2019;20(21):5488. Published 2019 Nov 4. [Content Brief]
- [4]. Jeong SI, et al. Continentalic acid from Aralia continentalis shows activity against methicillin-resistant Staphylococcus aureus. Phytother Res. 2006;20(6):511-514. [Content Brief]
- [5]. Zafar S, et al. Neuroprotective effect of Continentalic acid by targeting NF-κB/Bcl-2 and oxidative stress signaling in traumatic brain injury in male BALB/c mice. Mol Biol Rep. 2025;53(1):135. Published 2025 Nov 28. [Content Brief]
