20493-56-5
Chemical Structure
Curzerenone
- CAS No.: 20493-56-5
- Formula:C15H18O2
- Molecular Weight:230.30
IUPAC Name: (5R,6R)-3,6-dimethyl-5-(prop-1-en-2-yl)-6-vinyl-6,7-dihydrobenzofuran-4(5H)-one
InChIKey: ZVMJXSJCBLRAPD-ZFWWWQNUSA-N
SMILES: O=C1C2=C(OC=C2C)C[C@@](C=C)(C)[C@H]1C(C)=C
Biological Activity: Curzerenone is an orally active sesquiterpene compound and Antibacterial agent. Curzerenone can be isolated from Curcuma zedoaria and Curcuma aeruginosa plants. Curzerenone increases ROS levels, activates Apoptotic signaling pathways, and attenuates the PI3K/AKT/mTOR signaling pathway. Curzerenone exhibits anticancer activity against liver cancer and cervical cancer. Curzerenone has antioxidant effects. Curzerenone shows weak antibacterial activity against Escherichia coli. Curzerenone can be used in research related to hepatocellular carcinoma, cervical cancer, and Escherichia coli infection[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Curzerenone | 98.55% | Curzerenone is an orally active sesquiterpene compound and Antibacterial agent. Curzerenone can be isolated from Curcuma zedoaria and Curcuma aeruginosa plants. Curzerenone increases ROS levels, activates Apoptotic signaling pathways, and attenuates the PI3K/AKT/mTOR signaling pathway. Curzerenone exhibits anticancer activity against liver cancer and cervical cancer. Curzerenone has antioxidant effects. Curzerenone shows weak antibacterial activity against Escherichia coli. Curzerenone can be used in research related to hepatocellular carcinoma, cervical cancer, and Escherichia coli infection. | ||||||||||||||||||||
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- [1]. Tian Y, et al. Sesquiterpene Curzerenone Activates Apoptotic Signaling and Attenuates PI3K/AKT/mTOR Signaling in HepG2 Cells by Triggering Oxidative Stress[J]. Pharmacognosy Magazine, 2026, 22(1): 395-406.
- [2]. Zhu X, et al. Inhibitory activities of curzerenone, curdione, furanodienone, curcumol and germacrone on Ca2+-activated chloride channels. Fitoterapia. 2020;147:104736. [Content Brief]
- [3]. Sun Y, et al. Curzerenone inactivates the nuclear factor-kappa B signaling to suppress malignancy and immune evasion in cervical cancer by targeting CSNK2B. Hum Cell. 2024;38(1):35. Published 2024 Dec 24. [Content Brief]
- [4]. Joshi SC, et al. Antioxidant and antibacterial activities of the leaf essential oil and its constituents furanodienone and curzerenone from Lindera pulcherrima (Nees.) Benth. ex hook. f. Pharmacognosy Res. 2012 Apr;4(2):80-4. [Content Brief]
Keywords
