2055746-08-0
2055746-08-0
Chemical Structure
EGFR-IN-159
- CAS No.: 2055746-08-0
- Formula:C21H23N3O5
- Molecular Weight:397.42
InChIKey: VSSKTNWJCNIPJN-UHFFFAOYSA-N
SMILES: OC1=C(OCC)C=C(C2C(C(NC3=C(OC)C=CC=C3)=O)=C(C)NC(N2)=O)C=C1
Biological Activity: EGFR-IN-159 (compound 12), a dihydropyrimidine, is a potent EGFR inhibitor with an IC50 value of 29.00 nM. EGFR-IN-159 exhibits dose-dependent inhibition against EGFR and HER2. EGFR-IN-159 shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC50 values of 16.07 μg/mL and 35.98 μg/mL, respectively. EGFR-IN-159 has no BBB permeation. EGFR-IN-159 shows appreciable anti-cancer activity[1].
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EGFR-IN-159 | EGFR-IN-159 (compound 12), a dihydropyrimidine, is a potent EGFR inhibitor with an IC50 value of 29.00 nM. EGFR-IN-159 exhibits dose-dependent inhibition against EGFR and HER2. EGFR-IN-159 shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC50 values of 16.07 μg/mL and 35.98 μg/mL, respectively. EGFR-IN-159 has no BBB permeation. EGFR-IN-159 shows appreciable anti-cancer activity. | |||||||||||||||||||||
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