206129-88-6
Chemical Structure
KF26777 free base
- CAS No.: 206129-88-6
- Formula:C16H16BrN5O
- Molecular Weight:374.24
IUPAC Name: 2-(4-bromophenyl)-4-propyl-1,4,7,8-tetrahydro-5H-imidazo[2,1-i]purin-5-one
InChIKey: GYGNZJDWTHECQT-UHFFFAOYSA-N
SMILES: O=C1N(CCC)C2=C(NC(C3=CC=C(Br)C=C3)=N2)C4=NCCN14
Biological Activity: KF26777 (free base) is a potent and selective adenosine A3 receptor antagonist with an Ki value of 0.2 nM and possesses 9000-, 2350- and 3100-fold selectivity against adenosine A1, A2A and A2B receptors, respectively. KF26777 (free base) potently inhibits the [125I]AB-MECA binding to adenosine A3 receptors. KF26777 (free base) is promising for research of brain ischemia and inflammatory disease including asthma[1].
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KF26777 free base | KF26777 (free base) is a potent and selective adenosine A3 receptor antagonist with an Ki value of 0.2 nM and possesses 9000-, 2350- and 3100-fold selectivity against adenosine A1, A2A and A2B receptors, respectively. KF26777 (free base) potently inhibits the [125I]AB-MECA binding to adenosine A3 receptors. KF26777 (free base) is promising for research of brain ischemia and inflammatory disease including asthma. | |||||||||||||||||||||
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Keywords
