KF26777 free base
KF26777 (free base) is a potent and selective adenosine A3 receptor antagonist with an Ki value of 0.2 nM and possesses 9000-, 2350- and 3100-fold selectivity against adenosine A1, A2A and A2B receptors, respectively. KF26777 (free base) potently inhibits the [125I]AB-MECA binding to adenosine A3 receptors. KF26777 (free base) is promising for research of brain ischemia and inflammatory disease including asthma.
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- CAS No.: 206129-88-6
- Formule: C16H16BrN5O
- Masse moléculaire:374.24
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
270 nM
Compound: 67, KF26777
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Antagonist activity at human adenosine A3 receptor expressed in CHO cells by [S35]GTPgammaS binding assay
Antagonist activity at human adenosine A3 receptor expressed in CHO cells by [S35]GTPgammaS binding assay
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[PMID: 22468757] |
Chemical Information
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CAS No. 206129-88-6
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Masse moléculaire 374.24
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Formule C16H16BrN5O
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SMILES
O=C1N(CCC)C2=C(NC(C3=CC=C(Br)C=C3)=N2)C4=NCCN14
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KF26777 free base Related Classifications
HY-119191 Related Classifications
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