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Cat. No.: HY-119191

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KF26777 free base

KF26777 (free base) is a potent and selective adenosine A3 receptor antagonist with an K_i value of 0.2 nM and possesses 9000-, 2350- and 3100-fold selectivity against adenosine A1, A2A and A2B receptors, respectively. KF26777 (free base) potently inhibits the [125I]AB-MECA binding to adenosine A3 receptors. KF26777 (free base) is promising for research of brain ischemia and inflammatory disease including asthma.

For research use only. We do not sell to patients.

CAS No.: 206129-88-6
Formula: C₁₆H₁₆BrN₅O
Molecular Weight:374.24

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

KF26777 free base Chemical Structure

CAS No.: 206129-88-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Adenosine Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	270 nM Compound: 67, KF26777	Antagonist activity at human adenosine A3 receptor expressed in CHO cells by [S35]GTPgammaS binding assay Antagonist activity at human adenosine A3 receptor expressed in CHO cells by [S35]GTPgammaS binding assay	[PMID: 22468757]

Chemical Information

CAS No. 206129-88-6
Molecular Weight 374.24
Formula C₁₆H₁₆BrN₅O
SMILES

O=C1N(CCC)C2=C(NC(C3=CC=C(Br)C=C3)=N2)C4=NCCN14
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Saki M, et al. KF26777 (2-(4-bromophenyl)-7,8-dihydro-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one dihydrochloride), a new potent and selective adenosine A3 receptor antagonist. Eur J Pharmacol. 2002 May 31;444(3):133-41. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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References

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KF26777 free base

All Adenosine Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

KF26777 free base Related Classifications

HY-119191 Related Classifications