2119040-02-5

JAK-IN-44 Chemical Structure
2119040-02-5

Chemical Structure

JAK-IN-44

  • CAS No.: 2119040-02-5
  • Formula:C18H21N7O2S
  • Molecular Weight:399.47

InChIKey: FMPVHEWUXRWOKK-UHFFFAOYSA-N

SMILES: N#CCC1(CCN(S(=O)(CC)=O)CC1)N2N=CC(C3=C4C=CNC4=NC=N3)=C2

Biological Activity: JAK-IN-44 is an orally active and selective JAK2 inhibitor, with IC50 values of 0.2 nM, 7.3 nM, 21 nM and 27 nM against JAK2, TYK2, JAK1 and JAK3, respectively. JAK-IN-44 inhibits disease phenotypes in adjuvant-induced arthritis, systemic lupus erythematosus and experimental autoimmune uveitis models, and improves the survival rate of mice in LPS (HY-D1056)-induced sepsis models. JAK-IN-44 can be used in the research of autoimmune and inflammatory diseases such as systemic lupus erythematosus, uveitis, rheumatoid arthritis and sepsis[1][2][3][4].

Cat. No. Product Name Purity Description Pricing
HY-188034 		JAK-IN-44 JAK-IN-44 is an orally active and selective JAK2 inhibitor, with IC50 values of 0.2 nM, 7.3 nM, 21 nM and 27 nM against JAK2, TYK2, JAK1 and JAK3, respectively. JAK-IN-44 inhibits disease phenotypes in adjuvant-induced arthritis, systemic lupus erythematosus and experimental autoimmune uveitis models, and improves the survival rate of mice in LPS (HY-D1056)-induced sepsis models. JAK-IN-44 can be used in the research of autoimmune and inflammatory diseases such as systemic lupus erythematosus, uveitis, rheumatoid arthritis and sepsis.
Pricing 
Expand Hide
loading...
/
  • /
loading...
Size Price
Stock Quantity Availability Operate
/
In-stock
(Estimated to ship on )
(Estimated to ship TODAY)
Estimated to ship on
(Estimated to ship TODAY)

Amount:

USD 0.00

This product is a controlled substance and not for sale in your territory.

This product is not for sale in your territory.

Pricing 
Expand Hide
References

Keywords