2173357-28-1
Chemical Structure
JNJ-64326067
- CAS No.: 2173357-28-1
- Formula:C15H12FN3
- Molecular Weight:253.28
IUPAC Name: N-(4-fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine
InChIKey: YKKAKBCEHOZBEQ-UHFFFAOYSA-N
SMILES: FC1=CC(=NC=C1C)NC=2C=CC=3C=NC=CC3C2
Biological Activity: JNJ-64326067 is an aggregated tau-binding agent with blood-brain barrier permeability, with a Ki of 2.4 nM. JNJ-64326067 selectively binds to aggregated tau protein but does not bind to aggregated β-amyloid protein, and shows no significant off-target binding to the tested receptors, ion channels, transporters, kinases or monoamine oxidases. JNJ-64326067 is applicable to the research of Alzheimer's disease[1].
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JNJ-64326067 | JNJ-64326067 is an aggregated tau-binding agent with blood-brain barrier permeability, with a Ki of 2.4 nM. JNJ-64326067 selectively binds to aggregated tau protein but does not bind to aggregated β-amyloid protein, and shows no significant off-target binding to the tested receptors, ion channels, transporters, kinases or monoamine oxidases. JNJ-64326067 is applicable to the research of Alzheimer's disease. | |||||||||||||||||||||
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