2227315-30-0
Chemical Structure
JMI-105
- CAS No.: 2227315-30-0
- Formula:C20H23N3O2
- Molecular Weight:337.42
IUPAC Name: 4-((5-isopropyl-2-methylphenoxy)methyl)-1-(4-methoxyphenyl)-1H-1,2,3-triazole
InChIKey: ISFDLMZYLHSBMQ-UHFFFAOYSA-N
SMILES: CC(C1=CC=C(C)C(OCC2=CN(C3=CC=C(OC)C=C3)N=N2)=C1)C
Biological Activity: JMI-105 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-105 inhibits the growth of CQS (3D7; IC50=8.8 µM) and CQR (RKL-9; IC50=14.3 µM) strains of P. falciparum. JMI-105 significantly decreases parasitemia and prolonged host survival in a murine model with P. berghei ANKA infection. JMI-105 has the potential to be used as an anti-malarial agent[1].
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JMI-105 | JMI-105 is a potent PfFP-2 (Plasmodium falciparum falcipain-2 protease) inhibitor. JMI-105 inhibits the growth of CQS (3D7; IC50=8.8 µM) and CQR (RKL-9; IC50=14.3 µM) strains of P. falciparum. JMI-105 significantly decreases parasitemia and prolonged host survival in a murine model with P. berghei ANKA infection. JMI-105 has the potential to be used as an anti-malarial agent. | |||||||||||||||||||||
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Keywords
