2238886-63-8
2238886-63-8
Chemical Structure
SCH-720881
- CAS No.: 2238886-63-8
- Formula:C25H26F6N2O3
- Molecular Weight:516.48
InChIKey: FCWJCWUZMPITLV-OYGALRCHSA-N
SMILES: C[C@H](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)OC[C@@]2(C3=CC=CC=C3)CC[C@@]4(NC(C[C@@H]4O)=O)CN2
Biological Activity: SCH-720881 is the active metabolite of Rolapitant (HY-14751). Rolapitant (SCH619734) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model[1].
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SCH-720881 | SCH-720881 is the active metabolite of Rolapitant (HY-14751). Rolapitant (SCH619734) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model. | |||||||||||||||||||||
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References
Keywords
