2244517-61-9
Chemical Structure
PDE5-IN-2
- CAS No.: 2244517-61-9
- Formula:C25H21N3O6S
- Molecular Weight:491.52
IUPAC Name: 3-(benzo[d][1,3]dioxol-5-ylmethyl)-8-hydroxy-6-((2-methoxyethyl)amino)-1-(thiazol-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one
InChIKey: VNWKVRSLWCIUCC-UHFFFAOYSA-N
SMILES: O=C1C2=C(C3=NC=CS3)NC(CC4=CC(OCO5)=C5C=C4)=C2OC6=CC(NCCOC)=CC(O)=C61
Biological Activity: PDE5-IN-2 is a potent, highly selective, and orally active PDE5 inhibitor, with an IC50 of 0.31 nM, less potently inhibits PDE2A, PDE10A, PDE4D2, and PDE6C, with IC50s of 106, 46, 43, 1.2 nM, respectively. Anti-pulmonary arterial hypertension activity[1].
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PDE5-IN-2 | PDE5-IN-2 is a potent, highly selective, and orally active PDE5 inhibitor, with an IC50 of 0.31 nM, less potently inhibits PDE2A, PDE10A, PDE4D2, and PDE6C, with IC50s of 106, 46, 43, 1.2 nM, respectively. Anti-pulmonary arterial hypertension activity. | |||||||||||||||||||||
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Keywords
