2247047-77-2
2247047-77-2
Chemical Structure
Tubulin inhibitor 35
- CAS. Nr.: 2247047-77-2
- Formula:C21H21N3O
- Molecular Weight:331.41
InChIKey: JSGWJWGKFPBVTK-UHFFFAOYSA-N
SMILES: O=C(N(CCC1=C2NC3=C1C=CC=C3)C2N4CCC)C5=C4C=CC=C5
Biological Activity: Tubulin inhibitor 35 (compound 6b) is a dual inhibitor of topoisomerase I (IC50=~50 μM) and tubulin polymerization (IC50=5.69 μM). Tubulin inhibitor 35 inhibits migration and invasion of MGC-803 and RKO cell lines，and induces apoptosis via arresting cell cycle at G2/M phase. Tubulin inhibitor 35 exhibis potent efficacy in gastrointestinal tumor inhibiton (inhibits MGC-803 (IC50=0.09 μM) and RKO (IC50=0.2 μM) cell lines)[1].
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Tubulin inhibitor 35 | Tubulin inhibitor 35 (compound 6b) is a dual inhibitor of topoisomerase I (IC50=~50 μM) and tubulin polymerization (IC50=5.69 μM). Tubulin inhibitor 35 inhibits migration and invasion of MGC-803 and RKO cell lines，and induces apoptosis via arresting cell cycle at G2/M phase. Tubulin inhibitor 35 exhibis potent efficacy in gastrointestinal tumor inhibiton (inhibits MGC-803 (IC50=0.09 μM) and RKO (IC50=0.2 μM) cell lines). | |||||||||||||||||||||
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