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Cat. No.: HY-155073

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Tubulin inhibitor 35

Name: Tubulin inhibitor 35
Brand: MedChemExpress
SKU: HY-155073
Price: 104.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Tubulin inhibitor 35 (compound 6b) is a dual inhibitor of topoisomerase I (IC₅₀=~50 μM) and tubulin polymerization (IC₅₀=5.69 μM). Tubulin inhibitor 35 inhibits migration and invasion of MGC-803 and RKO cell lines，and induces apoptosis via arresting cell cycle at G2/M phase. Tubulin inhibitor 35 exhibis potent efficacy in gastrointestinal tumor inhibiton (inhibits MGC-803 (IC₅₀=0.09 μM) and RKO (IC₅₀=0.2 μM) cell lines).

For research use only. We do not sell to patients.

CAS No.: 2247047-77-2
Formula: C₂₁H₂₁N₃O
Molecular Weight:331.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Tubulin inhibitor 35 Chemical Structure

CAS No.: 2247047-77-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
GES1	IC₅₀	0.13 μM Compound: 6b	Antiproliferative activity against human GES1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human GES1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37099835]
HGC-27	IC₅₀	0.81 μM Compound: 6b	Antiproliferative activity against human HGC-27 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HGC-27 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37099835]
LoVo	IC₅₀	0.23 μM Compound: 6b	Antiproliferative activity against human LoVo cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human LoVo cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37099835]
MGC-803	IC₅₀	0.09 μM Compound: 6b	Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37099835]
RKO	IC₅₀	0.2 μM Compound: 6b	Antiproliferative activity against human RKO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human RKO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37099835]
SGC-7901	IC₅₀	0.09 μM Compound: 6b	Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37099835]
SW480	IC₅₀	0.71 μM Compound: 6b	Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37099835]

Chemical Information

CAS No. 2247047-77-2
Molecular Weight 331.41
Formula C₂₁H₂₁N₃O
SMILES

O=C(N(CCC1=C2NC3=C1C=CC=C3)C2N4CCC)C5=C4C=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Deng J, et al. N(14)-substituted evodiamine derivatives as dual topoisomerase 1/tubulin-Inhibiting anti-gastrointestinal tumor agents. Eur J Med Chem. 2023 Jul 5;255:115366. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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