Tubulin inhibitor 35

Cat. No.: HY-155073: Data Sheet Handling Instructions
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Tubulin inhibitor 35 (compound 6b) is a dual inhibitor of topoisomerase I (IC₅₀=~50 μM) and tubulin polymerization (IC₅₀=5.69 μM). Tubulin inhibitor 35 inhibits migration and invasion of MGC-803 and RKO cell lines，and induces apoptosis via arresting cell cycle at G2/M phase. Tubulin inhibitor 35 exhibis potent efficacy in gastrointestinal tumor inhibiton (inhibits MGC-803 (IC₅₀=0.09 μM) and RKO (IC₅₀=0.2 μM) cell lines).

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Tubulin inhibitor 35 Chemical Structure

CAS No. : 2247047-77-2

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1 mg	Get quote 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
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25 mg	Get quote 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 mg	Get quote 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
GES1	IC₅₀	0.13 μM Compound: 6b	Antiproliferative activity against human GES1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human GES1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37099835]
HGC-27	IC₅₀	0.81 μM Compound: 6b	Antiproliferative activity against human HGC-27 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HGC-27 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37099835]
LoVo	IC₅₀	0.23 μM Compound: 6b	Antiproliferative activity against human LoVo cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human LoVo cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37099835]
MGC-803	IC₅₀	0.09 μM Compound: 6b	Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37099835]
RKO	IC₅₀	0.2 μM Compound: 6b	Antiproliferative activity against human RKO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human RKO cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37099835]
SGC-7901	IC₅₀	0.09 μM Compound: 6b	Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37099835]
SW480	IC₅₀	0.71 μM Compound: 6b	Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 37099835]

Molecular Weight

331.41

Formula

C₂₁H₂₁N₃O

CAS No.

2247047-77-2

SMILES

O=C(N(CCC1=C2NC3=C1C=CC=C3)C2N4CCC)C5=C4C=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Deng J, et al. N(14)-substituted evodiamine derivatives as dual topoisomerase 1/tubulin-Inhibiting anti-gastrointestinal tumor agents. Eur J Med Chem. 2023 Jul 5;255:115366. [Content Brief]