2303508-09-8
Chemical Structure
P-gp inhibitor 15
- CAS No.: 2303508-09-8
- Formula:C35H60N2O4
- Molecular Weight:572.86
InChIKey: FRLGWRYFNSFURN-VUQOTYAVSA-N
SMILES: C[C@@]12[C@](C([C@H](CC1)NC([C@@H]3CCCN3)=O)(C)C)(CC[C@]4(C)[C@]2([H])C[C@@H](O)[C@@]5([H])[C@@]4(C)CC[C@@H]5[C@]6(C)CC[C@H](C(C)(C)O)O6)[H]
Biological Activity: P-gp inhibitor 15 (compound 7a) is a nonsubstrate inhibitor of P-glycoprotein (Pgp). P-gp inhibitor 15 inhibits Pgp-ATPase activity，and interfers Pgp-mediated Rhodamine123 efflux. P-gp inhibitor 15 also enhances the inhibitory efficacy of Paclitaxel (HY-B0015)，inhibits tumor progress in nude mice KBV xenograft tumors model[1].
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P-gp inhibitor 15 | P-gp inhibitor 15 (compound 7a) is a nonsubstrate inhibitor of P-glycoprotein (Pgp). P-gp inhibitor 15 inhibits Pgp-ATPase activity，and interfers Pgp-mediated Rhodamine123 efflux. P-gp inhibitor 15 also enhances the inhibitory efficacy of Paclitaxel (HY-B0015)，inhibits tumor progress in nude mice KBV xenograft tumors model. | |||||||||||||||||||||
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Keywords
