2305060-41-5
Chemical Structure
Flotufolastat
Synonym(s): rhPSMA-7.3
- CAS No.: 2305060-41-5
- Formula:C63H99FN12O25Si
- Molecular Weight:1471.61
IUPAC Name: (3S,7S,12R,26R,29R,34S)-29-((4-(di-tert-butylfluorosilyl)benzamido)methyl)-5,10,17,20,28,31-hexaoxo-34-(4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl)-4,6,11,16,21,27,30-heptaazatetratriacontane-1,3,7,12,26,34-hexacarboxylic acid
InChIKey: QMGJNAVROCDAIW-YNVJYXMMSA-N
SMILES: CC(C)(C)[Si](F)(C1=CC=C(C=C1)C(NC[C@@H](NC(CC[C@H](N2CCN(CCN(CCN(CC2)CC(O)=O)CC(O)=O)CC(O)=O)C(O)=O)=O)C(N[C@@H](C(O)=O)CCCCNC(CCC(NCCC[C@H](C(O)=O)NC(CC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)=O)=O)=O)=O)C(C)(C)C
Biological Activity: Flotufolastat is a prostate-specific membrane antigen (PSMA) modulator. Flotufolastat is also a radiodiagnostic agent used in prostate cancer imaging. Flotufolastat can be used in research on prostate cancer and other cancers[1][2].
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Flotufolastat | Flotufolastat is a prostate-specific membrane antigen (PSMA) modulator. Flotufolastat is also a radiodiagnostic agent used in prostate cancer imaging. Flotufolastat can be used in research on prostate cancer and other cancers. | |||||||||||||||||||||
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References
- [1]. Heo YA. Flotufolastat F 18: Diagnostic First Approval. Mol Diagn Ther. 2023 Sep;27(5):631-636. [Content Brief]
- [2]. Vogel MME, et al. Biochemical failure-free survival of 18F-rhPSMA-7 and 18F-flotufolastat PET-guided salvage radiotherapy for patients with recurrent prostate cancer. Sci Rep. 2025 Jan 17;15(1):2234. [Content Brief]
