2315320-24-0
Chemical Structure
PI3Kα-IN-8
- CAS No.: 2315320-24-0
- Formula:C26H27BrN4O2
- Molecular Weight:507.42
IUPAC Name: methyl (5aR,6R,9aS)-11-bromo-2-((4-cyanophenyl)amino)-6,9a-dimethyl-4,5,5a,6,7,8,9,9a-octahydro-3H-phenanthro[1,2-d]imidazole-6-carboxylate
InChIKey: UWTTZBMIXXRTND-LIKDZFNVSA-N
SMILES: C[C@@]12C3=CC(Br)=C(N=C(N4)NC5=CC=C(C=C5)C#N)C4=C3CC[C@@]1([H])[C@@](C)(CCC2)C(OC)=O
Biological Activity: PI3Kα-IN-8 (Compound 9g) is a selective PI3Kα inhibitor with an IC50 of 0.012 μM. PI3Kα-IN-8 increases intracellular reactive oxygen species level, decreases mitochondrial membrane potential and induces apoptosis[1].
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PI3Kα-IN-8 | PI3Kα-IN-8 (Compound 9g) is a selective PI3Kα inhibitor with an IC50 of 0.012 μM. PI3Kα-IN-8 increases intracellular reactive oxygen species level, decreases mitochondrial membrane potential and induces apoptosis. | |||||||||||||||||||||
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Keywords
