PI3Kα-IN-8
PI3Kα-IN-8 (Compound 9g) is a selective PI3Kα inhibitor with an IC50 of 0.012 μM. PI3Kα-IN-8 increases intracellular reactive oxygen species level, decreases mitochondrial membrane potential and induces apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 2315320-24-0
- Formula: C26H27BrN4O2
- Molecular Weight:507.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PI3Kα 0.012 μM (IC50) |
PI3Kδ 0.11 μM (IC50) |
PI3Kγ 0.18 μM (IC50) |
PI3Kβ 0.21 μM (IC50) |
PI3Kα-IN-8 (Compound 9g) exhibits anticancer activity with IC50 values of 0.18 ± 0.03, 0.43 ± 0.05, 0.71 ± 0.08 and 0.63 ± 0.09 μM against HCT-116, MCF-7, HeLa and HepG2 cells, respectively[1].
PI3Kα-IN-8 upregulates Bax and cleaved caspase-3/9 levels, and downregulates Bcl-2 level[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2315320-24-0
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Molecular Weight 507.42
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Formula C26H27BrN4O2
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SMILES
C[C@@]12C3=CC(Br)=C(N=C(N4)NC5=CC=C(C=C5)C#N)C4=C3CC[C@@]1([H])[C@@](C)(CCC2)C(OC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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