2319939-07-4
2319939-07-4
Chemical Structure
RepSox hydrochloride
Synonym(s): E-616452 hydrochloride; SJN 2511 hydrochloride
- CAS No.: 2319939-07-4
- Formula:C17H14ClN5
- Molecular Weight:323.78
InChIKey: ZKLHJSQURWMEIX-UHFFFAOYSA-N
SMILES: CC1=NC(C2=NNC=C2C3=CC=C4N=CC=CC4=N3)=CC=C1.Cl
Biological Activity: RepSox hydrochloride is a potent and selective inhibitor of transforming growth factor-β receptor I/activin-like kinase 5 (TGF-β-RI/ALK5). RepSox hydrochloride inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox hydrochloride can be used in the study of obesity and related metabolic diseases such as type 2 diabetes.
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RepSox hydrochloride | RepSox hydrochloride is a potent and selective inhibitor of transforming growth factor-β receptor I/activin-like kinase 5 (TGF-β-RI/ALK5). RepSox hydrochloride inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox hydrochloride can be used in the study of obesity and related metabolic diseases such as type 2 diabetes. | |||||||||||||||||||||
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