2353563-15-0
Chemical Structure
PROTAC STK4 Degrader-1
- CAS No.: 2353563-15-0
- Formula:C52H61FN8O13S
- Molecular Weight:1057.15
IUPAC Name: N-(3-((4-(6-amino-5-(1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)pyridin-3-yl)-N-cyclopropyl-3-fluorophenyl)sulfonamido)propyl)-1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaoctadecan-18-amide
InChIKey: KSYATOJPSUFTPA-UHFFFAOYSA-N
SMILES: O=C1NCCC2=C1C=CC(C3=CC(C4=C(F)C=C(S(=O)(N(C5CC5)CCCNC(CCOCCOCCOCCOCCOCCNC6=CC=CC(C(N7C8C(NC(CC8)=O)=O)=O)=C6C7=O)=O)=O)C=C4)=CN=C3N)=C2
Biological Activity: PROTAC STK4 Degrader-1 is a cereblon-recruiting STK4 PROTAC degrader. PROTAC STK4 Degrader-1 mediates ubiquitination and proteasomal degradation of STK4, induces dose- and time-dependent downregulation of STK4 in cancer cells, and exhibits reduced cytotoxicity in cereblon-knockout cells. PROTAC STK4 Degrader-1 can be used in research related to multiple myeloma[1].
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PROTAC STK4 Degrader-1 | PROTAC STK4 Degrader-1 is a cereblon-recruiting STK4 PROTAC degrader. PROTAC STK4 Degrader-1 mediates ubiquitination and proteasomal degradation of STK4, induces dose- and time-dependent downregulation of STK4 in cancer cells, and exhibits reduced cytotoxicity in cereblon-knockout cells. PROTAC STK4 Degrader-1 can be used in research related to multiple myeloma. | |||||||||||||||||||||
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