2361241-23-6

BI-749327 Chemical Structure
2361241-23-6

Chemical Structure

BI-749327

  • CAS No.: 2361241-23-6
  • Formula:C23H21F3N4O2
  • Molecular Weight:442.43

IUPAC Name: (4-(6-aminopyridazin-3-yl)piperidin-1-yl)(4-(4-(trifluoromethyl)phenoxy)phenyl)methanone

InChIKey: RGYMFGHHIDRCBN-UHFFFAOYSA-N

SMILES: NC1=NN=C(C2CCN(C(C3=CC=C(OC4=CC=C(C(F)(F)F)C=C4)C=C3)=O)CC2)C=C1

Biological Activity: BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7[1].

Cat. No. Product Name Purity Description Pricing
HY-111925 		BI-749327 99.95% BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7.
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