2361241-23-6
2361241-23-6
Chemical Structure
BI-749327
- CAS No.: 2361241-23-6
- Formula:C23H21F3N4O2
- Molecular Weight:442.43
IUPAC Name: (4-(6-aminopyridazin-3-yl)piperidin-1-yl)(4-(4-(trifluoromethyl)phenoxy)phenyl)methanone
InChIKey: RGYMFGHHIDRCBN-UHFFFAOYSA-N
SMILES: NC1=NN=C(C2CCN(C(C3=CC=C(OC4=CC=C(C(F)(F)F)C=C4)C=C3)=O)CC2)C=C1
Biological Activity: BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7[1].
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BI-749327 | 99.95% | BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7. | ||||||||||||||||||||
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BI-749327 (Standard) | ≥98% | BI-749327 (Standard) is the analytical standard of BI-749327 (HY-111925). This product is intended for research and analytical applications. BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7. | ||||||||||||||||||||
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