2389060-50-6
Chemical Structure
Linvemastat
Synonym(s): FP-020
- CAS No.: 2389060-50-6
- Formula:C20H17N3O4S
- Molecular Weight:395.43
InChIKey: GUKPADSDFUIAMC-UHFFFAOYSA-N
SMILES: O=C1NC(C(C2=C(SC3=CC=C(C=C3)OCC4=CC(C)=NC=C4)C=CO2)N1)=O
Biological Activity: Linvemastat (Compound FC-4) is an orally active MMP-12 inhibitor (IC50: < 10 nM) with high selectivity of MMP-1, -2, -3, -7, -9, -10 and -14. Linvemastat significantly attenuates lung fibrosis in Bleomycin (HY-108345) induced unilateral lung fibrosis mice model and potently reduces kidney damage, interstitial inflammation or fibrosis in kidney fibrosis model of unilateral ureteral occlusion. Linvemastat can be used for inflammatory diseases research, such as idiopathie pulmonary fibrosis (IPF), inflammatory bowel disease (IBD) and asthma[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Linvemastat | 98.30% | Linvemastat (Compound FC-4) is an orally active MMP-12 inhibitor (IC50: < 10 nM) with high selectivity of MMP-1, -2, -3, -7, -9, -10 and -14. Linvemastat significantly attenuates lung fibrosis in Bleomycin (HY-108345) induced unilateral lung fibrosis mice model and potently reduces kidney damage, interstitial inflammation or fibrosis in kidney fibrosis model of unilateral ureteral occlusion. Linvemastat can be used for inflammatory diseases research, such as idiopathie pulmonary fibrosis (IPF), inflammatory bowel disease (IBD) and asthma. | ||||||||||||||||||||
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Keywords
