2399455-71-9
Chemical Structure
Lenalidomide 4'-alkyl-C3-azide
- CAS No.: 2399455-71-9
- Formula:C16H18N6O3
- Molecular Weight:342.35
InChIKey: BUOALKMQQKQMCO-UHFFFAOYSA-N
SMILES: [N-]=[N+]=NCCCNC1=CC=CC2=C1CN(C3C(NC(CC3)=O)=O)C2=O
Biological Activity: Lenalidomide 4'-alkyl-C3-azide (compound 4a) is a click chemical modified Lenalidomide (HY-A0003) that can be used to synthesize PROTACs. Lenalidomide is an orally active immunomodulator and a ligand for the ubiquitin E3 ligase cereblon (CRBN). Lenalidomide 4'-alkyl-C3-azide contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition reactions (SPAAC) can also occur with molecules containing DBCO or BCN groups[1].
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Lenalidomide 4'-alkyl-C3-azide | Lenalidomide 4'-alkyl-C3-azide (compound 4a) is a click chemical modified Lenalidomide (HY-A0003) that can be used to synthesize PROTACs. Lenalidomide is an orally active immunomodulator and a ligand for the ubiquitin E3 ligase cereblon (CRBN). Lenalidomide 4'-alkyl-C3-azide contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition reactions (SPAAC) can also occur with molecules containing DBCO or BCN groups. | |||||||||||||||||||||
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Keywords
