2409479-24-7
Chemical Structure
IDO/Tubulin-IN-2
- CAS No.: 2409479-24-7
- Formula:C48H40N6O10
- Molecular Weight:860.87
IUPAC Name: (Z)-2-(1-(3-((2-methoxy-5-(3,4,5-trimethoxystyryl)phenoxy)carbonyl)benzyl)-1H-1,2,3-triazol-4-yl)ethyl 3-((4,9-dioxo-4,9-dihydro-1H-naphtho[2,3-d][1,2,3]triazol-1-yl)methyl)benzoate
InChIKey: BYONMJRCXBUVGH-NXVVXOECSA-N
SMILES: COC1=CC=C(C=C1OC(C2=CC=CC(CN3C=C(N=N3)CCOC(C4=CC=CC(CN5N=NC6=C5C(C7=CC=CC=C7C6=O)=O)=C4)=O)=C2)=O)/C=C\C8=CC(OC)=C(C(OC)=C8)OC
Biological Activity: IDO/Tubulin-IN-2 (HT2) is a potent TDO and tubulin inhibitor. IDO/Tubulin-IN-2 also shows potent activity against U87, HepG2, A549, HCT-116, and LO2 cancer cell lines, with IC50 values of 0.43, 0.036, 0.041, 0.095 and 1.04 μM, respectively. IDO/Tubulin-IN-2 remarkably promotes the antitumor activity[1].
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IDO/Tubulin-IN-2 | IDO/Tubulin-IN-2 (HT2) is a potent TDO and tubulin inhibitor. IDO/Tubulin-IN-2 also shows potent activity against U87, HepG2, A549, HCT-116, and LO2 cancer cell lines, with IC50 values of 0.43, 0.036, 0.041, 0.095 and 1.04 μM, respectively. IDO/Tubulin-IN-2 remarkably promotes the antitumor activity. | |||||||||||||||||||||
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Keywords
