2411429-33-7
Chemical Structure
NCT-58
- CAS No.: 2411429-33-7
- Formula:C27H34N2O5
- Molecular Weight:466.57
IUPAC Name: 5-methoxy-N-(3-methoxy-4-(2-(piperidin-2-yl)ethoxy)phenyl)-2,2-dimethyl-2H-chromene-6-carboxamide
InChIKey: QGEKYFVMAGLOKW-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2OC(C)(C)C=CC2=C1OC)NC3=CC=C(C(OC)=C3)OCCC4NCCCC4
Biological Activity: NCT-58 is a potent inhibitor of C-terminal HSP90. NCT-58 does not induce the heat shock response (HSR) due to its targeting of the C-terminal region and elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation. NCT-58 kills Trastuzumab-resistant breast cancer stem-like cells. NCT-58 induces apoptosis in HER2-positive breast cancer cells[1].
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NCT-58 | 99.63% | NCT-58 is a potent inhibitor of C-terminal HSP90. NCT-58 does not induce the heat shock response (HSR) due to its targeting of the C-terminal region and elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation. NCT-58 kills Trastuzumab-resistant breast cancer stem-like cells. NCT-58 induces apoptosis in HER2-positive breast cancer cells. | ||||||||||||||||||||
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