2414393-48-7
2414393-48-7
Chemical Structure
(S)-Benzyl 2-cyclopropyl-2-hydroxyacetate
- CAS No.: 2414393-48-7
- Formula:C12H14O3
- Molecular Weight:206.24
InChIKey: HBEZCBDGJMYNGS-NSHDSACASA-N
SMILES: O=C(OCC1=CC=CC=C1)[C@H](C2CC2)O
Biological Activity: (S)-Benzyl 2-cyclopropyl-2-hydroxyacetate is an intermediate reactant in the synthesis of Camptothecin (HY-16560). Camptothecin is an inhibitor of the DNA topoisomerase Topo I, withIC50=679 nM[1][2].
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(S)-Benzyl 2-cyclopropyl-2-hydroxyacetate | (S)-Benzyl 2-cyclopropyl-2-hydroxyacetate is an intermediate reactant in the synthesis of Camptothecin (HY-16560). Camptothecin is an inhibitor of the DNA topoisomerase Topo I, withIC50=679 nM. | |||||||||||||||||||||
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References
- [1]. Li Zhen, et al. Camptothecin derivative, and pharmaceutical composition and use thereof. World Intellectual Property Organization, WO2023020605 A1. 2023-02-23.
- [2]. Huang Q, et al. Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents. Eur J Med Chem. 2013;63:746-757. [Content Brief]
