2416593-55-8
2416593-55-8
Chemical Structure
ZB-R-55
- CAS No.: 2416593-55-8
- Formula:C25H23N5O3
- Molecular Weight:441.48
InChIKey: QDIMLDKKJUQINI-IBGZPJMESA-N
SMILES: CN1C2=CC(C#CC3CC3)=CC=C2OC[C@H](NC(C4=NC(CC5=CC=CC=C5)=NN4)=O)C1=O
Biological Activity: ZB-R-55 is an orally active and selective dual-mode RIPK1 inhibitor with RIPK1 IC50 values of 5.7 nM. ZB-R-55 occupies both the allosteric and ATP binding sites of RIPK1. ZB-R-55 inhibits necroptosis in cancer cells. ZB-R-55 can be used for the research of systemic inflammatory response syndrome and sepsis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ZB-R-55 | 99.39% | ZB-R-55 is an orally active and selective dual-mode RIPK1 inhibitor with RIPK1 IC50 values of 5.7 nM. ZB-R-55 occupies both the allosteric and ATP binding sites of RIPK1. ZB-R-55 inhibits necroptosis in cancer cells. ZB-R-55 can be used for the research of systemic inflammatory response syndrome and sepsis. | ||||||||||||||||||||
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References
- [1]. Yang X, et al. Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis. Angew Chem Int Ed Engl. 2022;61(5):e202114922. [Content Brief]
- [2]. Zhou Y, et al. Necroptosis inhibitors: mechanisms of action and therapeutic potential. Apoptosis. 2024;29(1-2):22-44. [Content Brief]
Keywords
