2448475-08-7
Chemical Structure
KDOAM-25 citrate
- CAS No.: 2448475-08-7
- Formula:C21H33N5O9
- Molecular Weight:499.51
IUPAC Name: 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinamide 2-hydroxypropane-1,2,3-tricarboxylate
InChIKey: LOVVSPOOXGDJRT-UHFFFAOYSA-N
SMILES: NC(C1=CC=NC(CNCC(N(CC)CCN(C)C)=O)=C1)=O.OC(CC(C(O)=O)(O)CC(O)=O)=O
Biological Activity: KDOAM-25 citrate is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 citrate increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KDOAM-25 citrate | 98.56% | KDOAM-25 citrate is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 citrate increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells. | ||||||||||||||||||||
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Keywords
