2451070-32-7
Chemical Structure
L18I
- CAS No.: 2451070-32-7
- Formula:C47H51N11O8
- Molecular Weight:897.98
InChIKey: PQIHIELQKZACPK-LXJLEQQOSA-N
SMILES: O=C1C2=CC=CC(CCCOCCOCCOCCN3C=C(C(N4CCC[C@@H](N5N=C(C6=CC=C(OC7=CC=CC=C7)C=C6)C8=C5N=CN=C8N)C4)=O)N=N3)=C2CN1C9C(NC(CC9)=O)=O
Biological Activity: L18I is a PROTAC targeting Btk that can reduce inflammation in autoimmune diseases such as lupus erythematosus induced by BM12 splenocytes. The active control of the target protein ligand of L18I is IBT6A-CO-ethyne (HY-163963), and the conjugate of E3 ubiquitin ligase ligand + Linker of L18I is Lenalidomide-C3-PEG3-N3 (HY-163964)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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L18I | 99.43% | L18I is a PROTAC targeting Btk that can reduce inflammation in autoimmune diseases such as lupus erythematosus induced by BM12 splenocytes. The active control of the target protein ligand of L18I is IBT6A-CO-ethyne (HY-163963), and the conjugate of E3 ubiquitin ligase ligand + Linker of L18I is Lenalidomide-C3-PEG3-N3 (HY-163964). | ||||||||||||||||||||
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Keywords
