245514-32-3
Chemical Structure
S 33138
- CAS No.: 245514-32-3
- Formula:C22H23N3O2
- Molecular Weight:361.44
IUPAC Name: N-(4-(2-((3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydrochromeno[3,4-c]pyrrol-2(3H)-yl)ethyl)phenyl)acetamide
InChIKey: ZDZWIQDJFWTDAM-GHTZIAJQSA-N
SMILES: CC(NC(C=C1)=CC=C1CCN2C[C@@H]3[C@@H](C2)COC4=CC=C(C#N)C=C43)=O
Biological Activity: S33138 is a D3 receptor antagonist. S33138 inhibits addiction in animal models of addiction. S33138 reduces cognitive impairment in rodent and primate models of schizophrenia and Parkinson's disease. S33138 can be used in research on neurological disorders such as schizophrenia and Parkinson's disease[1][2].
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S 33138 | S33138 is a D3 receptor antagonist. S33138 inhibits addiction in animal models of addiction. S33138 reduces cognitive impairment in rodent and primate models of schizophrenia and Parkinson's disease. S33138 can be used in research on neurological disorders such as schizophrenia and Parkinson's disease. | |||||||||||||||||||||
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- [1]. Peng XQ, et al.. The preferential dopamine D3 receptor antagonist S33138 inhibits cocaine reward and cocaine-triggered relapse to drug-seeking behavior in rats. Neuropharmacology. 2009 Mar;56(4):752-60. [Content Brief]
- [2]. Millan MJ, et al. The dopamine D3 receptor antagonist, S33138, counters cognitive impairment in a range of rodent and primate procedures. Int J Neuropsychopharmacol. 2010 Sep;13(8):1035-51. [Content Brief]
Keywords
