2490284-32-5
2490284-32-5
Chemical Structure
NN-429
- CAS No.: 2490284-32-5
- Formula:C17H15F5N2O4S
- Molecular Weight:438.37
InChIKey: IATMYBQDCZOCBN-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(CN(S(=O)(C2=CC(F)=C(C(F)=C2F)F)=O)C(C)C)C(F)=C1)NO
Biological Activity: NN-429 is a selective HDAC6 inhibitor. NN-429 induces apoptosis, increases the acetylation level of α-tubulin, and exhibits cytotoxicity against cancer cells. NN-429 is applicable to research related to acute myeloid leukemia, multiple myeloma and lymphoma[1][2].
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NN-429 | NN-429 is a selective HDAC6 inhibitor. NN-429 induces apoptosis, increases the acetylation level of α-tubulin, and exhibits cytotoxicity against cancer cells. NN-429 is applicable to research related to acute myeloid leukemia, multiple myeloma and lymphoma. | |||||||||||||||||||||
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References
- [1]. Patrick T. GUNNING, et al. Halogenated phenylsulfonamide hydroxamic acid compounds, compositions and uses thereof as selective hdac6 inhibitors. WO2020194272A1. 2021-09-27.
- [2]. Garcha HK, et al. High Efficacy and Drug Synergy of HDAC6-Selective Inhibitor NN-429 in Natural Killer (NK)/T-Cell Lymphoma. Pharmaceuticals (Basel). 2022;15(11):1321. Published 2022 Oct 26. [Content Brief]
Keywords
