2497504-72-8
Chemical Structure
hCAIX-IN-10
- CAS No.: 2497504-72-8
- Formula:C28H21N3O3S
- Molecular Weight:479.55
IUPAC Name: 2-(3-(2-oxo-2H-chromen-3-yl)-1-phenyl-1H-pyrazol-4-yl)-3-(m-tolyl)thiazolidin-4-one
InChIKey: LEWXJARBUCSXAX-UHFFFAOYSA-N
SMILES: O=C1N(C2=CC=CC(C)=C2)C(C3=CN(C4=CC=CC=C4)N=C3C5=CC6=CC=CC=C6OC5=O)SC1
Biological Activity: hCAIX-IN-10 (Compound 6i) is a selective carbonic anhydrase IX and XII inhibitor with Ki s of 61.5 and 586.8 nM for hCA IX and hCA XII, respectively. hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells[1].
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hCAIX-IN-10 | hCAIX-IN-10 (Compound 6i) is a selective carbonic anhydrase IX and XII inhibitor with Ki s of 61.5 and 586.8 nM for hCA IX and hCA XII, respectively. hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells. | |||||||||||||||||||||
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Keywords
