250608-67-4
250608-67-4
Chemical Structure
Sulindac sulfone-d3
- CAS No.: 250608-67-4
- Formula:C20H14D3FO4S
- Molecular Weight:375.43
IUPAC Name: (Z)-2-(5-fluoro-2-methyl-1-(4-((methyl-d3)sulfonyl)benzylidene)-1H-inden-3-yl)acetic acid
InChIKey: MVGSNCBCUWPVDA-FHFLIJIYSA-N
SMILES: OC(CC(C1=CC(F)=CC=C1/2)=C(C)C2=C\C3=CC=C(C=C3)S(C([2H])([2H])[2H])(=O)=O)=O
Biological Activity: Sulindac sulfone-d3 is deuterium labeled Sulindac sulfone.
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Sulindac sulfone-d3 | Sulindac sulfone-d3 is deuterium labeled Sulindac sulfone. | |||||||||||||||||||||
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Sulindac Sulfone-d6 | Sulindac Sulfone-d6 is the deuterium labeled Sulindac sulfone (HY-B1787). Sulindac sulfone is an mTORC1 pathway inhibitor and a metabolite of Sulindac. Sulindac sulfone inhibits colon cancer cell growth and induces cell cycle arrest. Sulindac sulfone is used in cancer research. | |||||||||||||||||||||
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Sulindac sulfone | 98.10% | Sulindac sulfone is an orally active metabolite of Sulindac (HY-B0008). Sulindac sulfone activates PPARγ and drives transcriptional induction of SSAT by binding to the PPRE-2 element. Sulindac sulfone induces Apoptosis. Sulindac sulfone negatively regulates the function of VDAC1/2 to inhibit the mTORC1 pathway, reduces Cyclin D1 levels, and induces G1 cell cycle arrest in colon cancer cells. Sulindac sulfone exerts colon cancer preventive effects through a COX-independent mechanism. Sulindac sulfone can be used in research related to colon cancer. | ||||||||||||||||||||
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