2568273-64-1

PROTAC SMARCA2/4 degrader-16 Chemical Structure
2568273-64-1

Chemical Structure

PROTAC SMARCA2/4 degrader-16

  • CAS No.: 2568273-64-1
  • Formula:C49H59N11O5S
  • Molecular Weight:914.13

InChIKey: SJPLQGPNFYKWGD-CRVYWEPASA-N

SMILES: NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N3CC4N(C5=NC=C([C@H]6CC[C@@H](CC6)C(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C9=C(N=CS9)C)C=C8)=O)=O)=O)C=N5)C(CC4)C3

Biological Activity: PROTAC SMARCA2/4-degrader-16 (compound I-337) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment[1].

Cat. No. Product Name Purity Description Pricing
HY-163869 		PROTAC SMARCA2/4 degrader-16 PROTAC SMARCA2/4-degrader-16 (compound I-337) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment.
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