2568277-68-7
Chemical Structure
PROTAC SMARCA2 degrader-5
- CAS No.: 2568277-68-7
- Formula:C57H72N12O5S
- Molecular Weight:1037.32
InChIKey: QVWYUXXXRJSGCA-GVOIIKGXSA-N
SMILES: O=C([C@H]1N(C([C@@H](NC(C2(CC3)CCC3(CN4CCC(C5=CN=C(N6C7CN(C8=CC(C9=CC=CC=C9O)=NN=C8N)CC6CC7)N=C5)CC4)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC%10=CC=C(C%11=C(C)N=CS%11)C=C%10
Biological Activity: PROTAC SMARCA2 degrader-5 (Compound I-425) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2 degrader-5 degrades SMARCA2 in MV411 and in A549 with DC50 <100 nM, degrades SMARCA4 with DC50 of 100-500 nM[1]. (Pink: Ligand for target protein (HY-159531); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))
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PROTAC SMARCA2 degrader-5 | PROTAC SMARCA2 degrader-5 (Compound I-425) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2 degrader-5 degrades SMARCA2 in MV411 and in A549 with DC50 <100 nM, degrades SMARCA4 with DC50 of 100-500 nM. (Pink: Ligand for target protein (HY-159531); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845)) | |||||||||||||||||||||
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Keywords
