2568523-81-7
Chemical Structure
PROTAC SMARCA2/4-degrader-4
- CAS No.: 2568523-81-7
- Formula:C56H66N10O5S
- Molecular Weight:991.25
InChIKey: UOTKDTAYBHIJCC-MTKLDLAJSA-N
SMILES: O=C([C@H]1N(C[C@H](O)C1)C([C@@H](NC([C@H](C2)C[C@@]32C[C@H](C4=CC=C(CN5CCC(CC5)CN6N=CC(C7=C(N)N=NC(C8=C(O)C=CC=C8)=C7)=C6)C=C4)C3)=O)C(C)(C)C)=O)NCC9=CC=C(C%10=C(C)N=CS%10)C=C9
Biological Activity: PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-4 degrades SMARCA2 in MV411 and in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 <100 nM. (Pink: Ligand for target protein (HY-159472); Black: Linker (HY-159478); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))[1]
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PROTAC SMARCA2/4-degrader-4 | PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-4 degrades SMARCA2 in MV411 and in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 <100 nM. (Pink: Ligand for target protein (HY-159472); Black: Linker (HY-159478); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845)) | |||||||||||||||||||||
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Keywords
